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姓 名: |
王晓雪 |
性 别: |
女 |
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职 务: |
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职 称: |
研究员 |
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学 历: |
博士研究生 |
通讯地址: |
广东省广州市海珠区新港西路164号 |
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电 话: |
020-89235490 |
邮政编码: |
510301 |
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传 真: |
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电子邮件: |
xxwang@scsio.ac.cn |
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| 简历： |
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王晓雪，博士，研究员，博士生导师，国家杰出青年基金获得者。2000年获中国海洋大学学士学位，2006年获美国德克萨斯农工大学博士学位，2007-2011年分别在美国新泽西州立大学、德克萨斯农工大学从事博士后研究。2012年入选中组部“青年”，2016年获得国家杰出青年基金资助，现任《中国科学：地球科学》、《Frontiers in Marine Sciences》编委、中国海洋湖沼学会微生物海洋学分会常务理事。近年来，围绕“生物被膜（Biofilm）形成及调控机制”这一关键科学问题，深入系统开展了原噬菌体、毒素-抗毒素系统等可移动遗传元件介导的水平基因转移在生物被膜形成中的作用及作用方式，并在珊瑚礁生态系统和深海等独特环境中的微生物互作方式与环境适应机制方面取得了系列创新性进展。先后主持国家重点基础研究发展计划（973计划）课题、国家基金重大项目课题和中国科学院战略性先导科技专项子课题等研究任务，以第一作者和通讯作者累计发表SCI论文30余篇。 |
| 研究领域： |
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1）模式细菌和海洋细菌生物被膜的基础及应用 |
| 获奖及荣誉： |
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1）国家青年获得者（2012） 2）国家杰出青年基金获得者（2016） 3）中科院特聘研究员骨干人才（2017） 4）科技部中青年科技创新领军人才（2017） |
| 代表论著： |
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1. Yao J, Guo Y, Wang P, Zeng Z, Li B, Tang K, Liu X, Wang XX* (2018). Type II toxinantitoxin system ParESO CopASO stabilizes prophage CP4So in Shewanella oneidensis. Environmental Microbiology. 2018, 20, 1224-1239. 2. Jia X, Yao J, Gao Z, Liu G, Dong Y, Wang XX* and Zhang H* (2018). Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin. Journal of Biological Chemistry. 293, 6812-6823. 3. Wang P, Zeng Z, Wang W, Wen Z, Li J, Wang XX* (2017). Dissemination and loss of a biofilm-related genomic island in marine Pseudoalteromonas mediated by integrative and conjugative elements. Environmental Microbiology. 19(11), 4620-4637. 4. Guo Y, Liu X, Li B, Yao J, Wood TK, Wang XX* (2017). Tail-anchored inner membrane protein ElaB increases resistance to stress while reducing persistence in Escherichia coli. Journal of Bacteriology. 199: e00057-17. 5. Zeng Z, Liu X, Yao J, Guo Y, Li B, Li Y, Jiao NZ, Wang XX* (2016). Cold adaptation regulated by cryptic prophage excision in Shewanella oneidensis. The ISME Journal. 10, 2787-2800. 6. Wang XX* and Wood TK* (2016). Cryptic prophages as targets for drug development. Drug Resistance Updates. 27:30-38. 7. Wang P, Yu Z, Li B, Cai X, Zeng Z, Chen X, Wang XX* (2015). Development of an efficient conjugation-based genetic manipulation system for Pseudoalteromonas. Microbial Cell Factories. 14:11. 8. Guo YX, Quiroga C, Chen Q, McAnulty MJ, Benedik MJ, Wood TK*, and Wang XX* (2014). RalR (a DNase) and RalA (a small RNA) form a type I toxin–antitoxin system in Escherichia coli. Nucleic Acids Research. 42 (10): 6448-6462. 9. Wang XX*, Lord DM, Hong SH, Peti W, Benedik MJ, Page R, and Wood TK* (2013). Type II toxinantitoxin MqsRMqsA controls type V toxinantitoxin GhoTGhoS. Environmental Microbiology. 15(6):1734-1744. 10. Wang XX, Lord DM, Cheng HY, Osbourne DO, Hong SH, Sanchez-Torres V, Quiroga C, Zheng K, Herrmann T, Peti W, Benedik MJ, Page R*, and Wood TK*(2012). A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nature Chemical Biology. 8(10):855-861. 11. Hong SH, Hegde M, Kim J, Wang XX, Jayaraman A*, Wood TK* (2012). Synthetic Quorum Sensing circuit to control consortial biofilm formation and dispersal in a microfluidic device. Nature Communications 3:613. 12. Wang XX, Kim Y, Hong SH, Ma Q, Brown BL, Pu M, Tarone AM, Benedik MJ, Peti W, Page R, and Wood TK (2011). Antitoxin MqsA helps mediate the bacterial general stress response. Nature Chemical Biology 7, 359-366. 13. Wang XX and Wood TK* (2011). Toxinantitoxin systems influence biofilm and persister cell formation and the general stress response. Applied Environmental Microbiology 77, 5577-5583. 14. Wang XX and Wood TK* (2011). IS5 inserts upstream of flhDC in a quasi-Lamarckian way. The ISME Journal 5, 1517–1525. 15. Wang XX, Kim Y, Ma Q, Hong SH, Pokusaeva K, Sturnio JM and Wood TK* (2010) Cryptic prophages help bacteria cope with adverse environments. Nature Communications 1, 147. 16. Wang XX, Kim Y, and Wood TK* (2009). Control and benefits of CP4-57 prophage excision in Escherichia coli biofilms. The ISME Journal 3, 1164-1179. |
| 承担科研项目情况： |
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1）国家杰出青年基金项目：微生物生理与代谢【31625001】，2017-2021 |
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