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姓 名: |
喻子牛 |
性 别: |
男 |
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职 务: |
中国科学院湛江海洋经济动物实验站站长 |
职 称: |
研究员 |
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学 历: |
博士研究生 |
通讯地址: |
广东省广州市海珠区新港西路164号 |
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电 话: |
020-89102507 |
邮政编码: |
510301 |
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传 真: |
020-89102507 |
电子邮件: |
carlzyu@scsio.ac.cn |
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| 简历： |
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喻子牛，博士，研究员。2005年初入选中科院“引进国外杰出人才计划”（），进入南海海洋研究所工作。1979-83年间于湖南师范大学生物系学习，获学士学位；1986年山东大学生物系研究生毕业，获硕士学位，同年进入青岛海洋大学，从事水产生物遗传学与育种学的教学和科研工作；1997年在青岛海洋大学获博士学位；1997-2004年间分别在美国两所大学（University of Delaware和The State University of New Jersey）作为博士后和研究员从事了5年多的海洋贝类遗传学与分子生物学研究。 |
| 研究领域： |
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1） 贝类遗传学与育种研究 (Genetics and Breeding Studies of Mollusks)：
开发、利用微卫星、线粒体DNA等分子标记，进行遗传多样性、群体遗传结构解析、育种过程中遗传变化的监测与评价、种类鉴定等；通过连锁分析进行遗传连锁图构建；利用家系选择、群体选择、杂交等方法和分子标记进行牡蛎优良品种培育；开展南海砗磲的人工繁育、培育和人工放流增殖，以及繁育、共生的分子基础和基因组研究。
2）贝类功能基因与基因组学 (Gene and Genomics Studies of Mollusks)： 通过性状相关的功能基因筛选、克隆、表达分析， 以及转录组、表达谱、蛋白组和基因组测序分析，解析、研究牡蛎等贝类的免疫、抗逆、生殖及其他生理过程或性状表达的分子基础，研究其分子水平的功能和调控，认识贝类生命过程机理，并为性状解析、良种培育提供可供利用的基因、基因组信息和工具。
3）贝类线粒体基因组与分子系统学 (Mitochondrial Genome and Molecular Phylogenetics in Mollusks)： 通过线粒体基因组测序和分析，运用分子系统学理论和方法，研究、比较贝类线粒体基因组的结构与变化、基因重排及其进化，进行种类鉴定；解析并探讨贝类种、属、科等各种类间、类群间的系统关系和地位。 |
| 获奖及荣誉： |
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1）中科院“”学者（2005）
2）广东省劳动模范（2015） |
| 代表论著： |
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1. Mao F., Y. Lin, Z. He, J. Li, Z. Xiang, Y. Zhang* and Z. Yu*,, 2018, Dual roles of cystatin A in the immune defense of the pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 75:190-197.
2. Zhang, Y., Y. Zhang, J. Li, Z. Yu*, 2016, Morphological and molecular evidence of hybridization events between two congeneric oysters, Crassostrea hongkongensis and C. ariakensis , in southern China. J. Mollus. Stud. In press.
3. Zhang, Y., Y. Zhang, J. Li, S. Xiao, Z. Xiang, Z. Wang*, X. Yan, Z. Yu*, 2016, Artificial interspecific backcrosses between the hybrid of female Crassostrea hongkongensis × male C. gigas and the two parental species. Aquaculture, 450:95-101.
4. Zhang, Y., J. Su, J. Li, Y. Zhang, S. Xiao, Z. Yu*, 2016, Survival and growth of reciprocal crosses between two stocks of the Hong Kong oyster Crassostrea hongkongensis (Lam & Morton, 2003) in southern China. Aquaculture Research, DOI: 10.1111are.13070
5. Tong, Y., Y. Zhang*, J. Huang, S. Xiao, Y. Zhang, Jun Li, J. Chen, Z. Yu*, 2015, Transcriptomics Analysis of Crassostrea hongkongensis for the Discovery of Reproduction-Related Gene. PLoS One, 10(8):e0134280.
6. Xu, F., Y. Zhang*, J. Li, Y. Zhang, Z. Xiang, Z. Yu, 2015, Expression and Function analysis of two Naturally Truncated MyD88 variants in the Pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 45:510-516.
7. Xu, F., J. Li, Y. Zhang, X. Li, Y. Zhang*, Z. Xiang, Z. Yu*, 2015, CgIκB3, the third novel inhibitor of NF-kappa B (IκB) protein, is involved in the immune defense of the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 46:648-655.
8. Zhang, Y., J. Sun , H. Mu , J. Li ,Y. Zhang , F. Xu , Z. Xiang, P Y. Qian , J. W. Qiu* and Z. Yu*, 2015, Proteomic basis of stress responses in the gills of the Pacific oyster Crassostrea gigas. J. Proteome Res. 14, 304？317.
9. Zhang, Y., Y. Zhang, Z. Wang*, X. Yan and Z. Yu*, 2014, Phenotypic trait analysis of diploid and triploid hybrids from female Crassostrea hongkongensis × male C. gigas. Aquaculture 434：307-314.
10. Li, J., Y. Zhang, Y. Zhang, Z. X.iang, Y. Tong, F. Qu and Z. Yu*, 2014, Genomic characterization and expression analysis of five novel IL-17 genes in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 40: 455-465.
11. Zhang, Y., F. Yu, J. Li, Y. Tong, Y. Zhang and Z. Yu*, 2014, The first invertebrate RIG-I-like receptor (RLR) homolog gene in the pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 40: 466-471.
12. Zhang, Y., J. Li, F. Yu, Y. Tong, Y. Zhang, X. Zhi and Z. Yu*, 2014, Identification and functional characterization of SIMPL in Crassostrea gigas reveals its ancient origin and involvement in the regulation of RelNF-κB transcription activity. Fish Shellfish Immunol. 40: 239-244.
13. Xia, J. X. Wu, S. Xiao, Z. Yu*, 2014, Mitochondrial DNA and morphological identification of a new cupped oyster species Crassostrea dianbaiensis (Bivalvia: Ostreidae) in the South China Sea. Aquat. Living Resour. 27, 41-48.
14. Huang, J., Y. Zhang, J. Li, Z. Yu*, 2014, Development of SNP markers in Crassostrea hongkongensis based on the next-generation sequencing and high resolution melting analysis. Conservation Genet Resour. 6:559–562.
15. Xiang, Z., F. Qu, L. Qi, Y. Tong, J. Li, S. Xiao, Z. Yu*, 2014, Cloning and characterization of an apoptosis-related DNA fragmentation factor (DFF) from oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 38: 119–126.
16. Zhang, Y., X. He, F. Yu, Z. Xiang, J. Li, K. L. Thorpe, Z. Yu*. 2013, Characteristic and functional analysis of Toll-like receptors (TLRs) in the lophotrocozoan, Crassostrea gigas, reveals ancient origin of TLR-mediated innate immunity. PLoS One. 8(10): e76464.
17. Xiang, Z., F. Qu, L. Qi,Y. Zhang, Z. Yu*, 2013, Cloning, characterization and expression analysis of a caspase-8 like gene from the Hong Kong oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 36:1797–1803.
18. Dineshram, R. V. Thiyagarajan, A. Lane, Z. Yu, S. Xiao, Priscilla T. Y. Leung. 2013, Elevated CO2 alters larval proteome and its phosphorylation status in the commercial oyster, Crassostrea hongkongensis. Mar Biol. 160(8):2189-2205.
19. Zhang, Y., Z. Wang*, X. Yan, Y. Zhang, S. Xiao, Z. Yu*, X. Guo, 2013, Dimorphic sterility of male hybrids of two oyster species, Crassostrea hongkongensis and C. gigas.
20. Ginger, W. K. Ko, B. S. Vera Chan, R. Dineshram, K. S. Dennis Choi, J. Adela Li, Z. Yu, V. Thiyagarajan. 2013, Larval and post-larval stages of Pacific oyster (Crassostrea gigas) are resistant to elevated CO2. PLoS One, 8(5): e64147.
21. Zhang, Y., J. Li, F. Yu, X. He and Z. Yu*, 2013, Allograft inflammatory factor-1 stimulates hemocyte immune activation by enhancing phagocytosis and expression of inflammatory cytokines in Crassostrea gigas. Fish Shellfish Immunol. 34:1071-1077.
22. Zhang, Y., Z. Yu*, 2013, The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas. Fish Shellfish Immunol. 34:1352-1355.
23. Li, J., J. Chen, Y. Zhang and Z. Yu*, 2013, Expression of Allograft inflammatory factor-1 (AIF-1) in response to bacterial challenge and tissue injury in the pearl oyster, Pinctada martensii. Fish Shellfish Immunol. 34:365-371.
24. Dineshram R, Wong K, Xiao S, Yu Z, Qian PY, Thiyagarajan V. 2012, Analysis of Pacific oyster larval proteome and its response to high-CO2. Mar. Pollution Bull. 64(10): 2160-7.
25. Yu, F., Y. Zhang and Z. Yu*, 2012, Characteristics and expression patterns of the Lipopolysaccharide- induced TNF-αfactor (LITAF) gene family in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 33:899-908.
26. Wu, X., X. Li, L. Li, X. Xu, J. Xia, Z. Yu*, 2012, New features of Asian Crassostrea oyster mitochondrial genomes: a novel alloacceptor tRNA gene recruitment and two novel ORFs. Gene 507: 112-118. $150.00
27. Chen, J., Xiao S., Z. Yu*, 2011, Molecular cloning, characterization and expression analysis of receptor for activated C kinase 1 (RACK1) from pearl oyster (Pinctada martensii) challenged with bacteria and exposed to cadmium. Fish Shellfish Immunol. 31: 781-787.
28. Zhang, Y., D. Fu, F. Yu, Q. Liu, Z. Yu*, 2011, Two catalase homologs are involved in host protection against bacterial infection and oxidative stress in Crassostrea hongkongensis. Fish Shellfish Immunol. 31:894-903.
29. Zhang, Y., X. He, Z. Yu*, 2011, Two homologues of inhibitor of NF-kappa B (IκB) are involved in the immune defense of the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol 30: 1354-1361.
30. He, X., Y. Zhang, Z. Yu*, 2011, An Mpeg (Macrophage expressed gene) from the Pacific oyster Crassostrea gigas: molecular characterization and gene expression. Fish Shellfish Immunol. 30:870-876.
31. Zhang, Y., X. He, X. Li, D. Fu, Chen, J., Z. Yu*, 2011, The second bactericidal permeability increasing protein (BPI) and its revelation of the gene duplication in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 30:954-963.
32. Wu, X., X. Xu, Z. Yu*, X. Kong, Z. Wei, J. Xia, 2010, Comparison of seven Crassostrea mitogenomes and phylogenetic analyses. Mol. Phylogenet. Evol. 57: 448–454.
33. Wu, X, X. Xu, Z. Yu*, J. Xia and X. Kong, 2009. Comparative mitogenomic analyses of three scallops (Bivalvia: Pectinidae) reveal high level variation of genomic organization and a diversity of transfer RNA gene sets. BMC Res. Note 2, 69: 7 pp.
34. Xia, J. and Z. Yu*, 2009, Identification of seven Crassostrea oysters from the South China Sea using PCR- RFLP analysis. J. Mollus. Stud. 75: 139-146.
35. Yu, Z., Z. Wei, X. Kong, W. Shi, 2008, Complete mitochondrial DNA sequence of oyster Crassostrea hongkongensis - a case of “Tandem duplication -random loss” for genome rearrangement in Crassostrea? BMC Genomics 9, 477: 13 pp.
36. Yu, Z. and X. Guo, 2006, Identification and mapping of disease-resistance QTLs in the Eastern oyster, Crassostrea virginica Gmelin. Aquaculture 54:160-170.
37. Yu, Z., Kong, X., Y. Jiang et al., 2005, Mitochondrial DNA sequence variation of Japanese anchovy (Engraulis japonicus) from the Yellow Sea and East China Sea. Fish. Sci. 71: 299-307.
38. Yu, Z. and X. Guo, 2004, Genetic analysis of selected strains of the Eastern oyster (Crassostrea virginica Gmelin) using AFLP and microsatellite markers. Mar. Biotechnol. 6:575-586.
39. Yu, Z. and X. Guo, 2003, Genetic linkage map of the Eastern oyster, Crassostrea virginica Gmelin. Biol. Bull. 204: 327-338. |
| 承担科研项目情况： |
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1）中国科学院先导专项A：岛礁功能生物种群恢复与重建，2016-2020
2）中科院STS项目：华南沿海牡蛎高效人工苗种生产技术的产业化集成应用和示范，2018-2019
3）广东省应用型科技研发专项：近江牡蛎和熊本牡蛎优异种质规模化高效扩繁技术研发 2016-2018
4）广州市科技计划项目，全基因组解析砗磲-虫黄藻共生关系建立的分子机制， 2018-2020；
5）国家基金课题：香港牡蛎和熊本牡蛎遗传连锁图谱构建及其杂交子代生长、糖原含量相关QTL分析，2018-2021
6）国家现代农业技术体系建设专项：牡蛎种质资源与品种改良，2016-2020
7）广东省海洋渔业科技与产业发展专项：熊本牡蛎高生长率新品种育种及技术研发，2016-2018 |
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