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姓 名: |
何毛贤 |
性 别: |
男 |
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职 务: |
广东省应用生物重点实验室副主任 |
职 称: |
研究员 |
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学 历: |
博士研究生 |
通讯地址: |
广东省广州市海珠区新港西路164号 |
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电 话: |
020-89023144 |
邮政编码: |
510301 |
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传 真: |
020-84458964 |
电子邮件: |
hmx@scsio.ac.cn |
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| 简历： |
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何毛贤，博士，研究员，博士生导师。1990年于西南师范大学获学士学位，1993年于武汉大学获硕士学位，2000年于中科院南海海洋研究所获博士学位。1993年进入南海海洋研究所工作，2001-2003年在广州南沙经济技术开发区-中国科学院广州分院企业博士后科研工作站进行博士后研究，担任海洋生物技术与遗传学科组长。“十三五”国家贝类产业技术体系岗位科学家，中国贝类学分会理事。主持国家“863”计划课题、NSFC-广东联合基金重点项目、国家自然科学基金面上项目、中国科学院先导专项A子课题、院知识创新项目课题、省自然科学基金和省科技计划项目等多项，发表论文90多篇（SCI论文40多篇），获授权国家发明专利12件、水产新品种1个、省部级科技奖3项。 |
| 研究领域： |
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1）海洋经济贝类的种质资源、遗传育种技术与新品种培育；
2）海洋贝类生长、抗逆、生殖发育等的分子遗传基础和调控机制；
3）海洋贝类新种质发掘，繁育、增殖放流。 |
| 代表论著： |
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1. Maoxian He, Yueguang Lin, Qi Shen et al. Production of tetraploid pearl oyster (Pinctada martensii Dunker) by inhibiting the first polar body in eggs from triploids. J. Shellfish Res., 2000, 19(1): 147-151.
2. Maoxian He, Weiguo Jiang, Liangmin Huang. Studies on aneuploid pearl oyster (Pinctada martensii Dunker) produced by crossing triploid females and a diploid male following the inhibition of PB1. Aquaculture, 2004, 230: 117-124.
3. Maoxian He, Liangmin Huang, Jianhua Shi, Yinping Jiang. The variability of ribosomal DNA ITS-2 and its utility in detecting genetic relatedness of pearl oyster. Marine Biotechnology, 2005, 7(1): 40-45.
4. Maoxian He, Yunyan Guan, Tao Yuan, Hongyu Zhang. Realized heritability and response to selection for shell height in the pearl oyster Pinctada fucata (Gould). Aquaculture Research, 2008, 39: 801-805.
5. Tao Yuan, Maoxian He*, Liangmin Huang*. Intraspecific genetic variation in mitochondrial 16S rRNA and COI genes in domestic and wild populations of Huaguizhikong scallop Chlamys nobilis Reeve. Aquaculture, 2009, 289: 19-25.
6. Tao Yuan, Maoxian He*, Liangmin Huang* and Jianxing Hu. Genetic linkage maps of huaguizhikong scallop Chlamys nobilis Reeve based on AFLP and micorsatellite markers. J Shellfish Res. 2010, 29(1): 55-62.
7. Lijuan Zhang, Maoxian He*. Quantitative expression of shell matrix protein genes and their correlations with shell traits in the pearl oyster Pinctada fucata. Aquaculture, 2011,314: 73-79.
8. LIU Wenguang, HE Maoxian*. Effects of ocean acidification on clearance, respiration and excretion rates of three species of bivalve molluscs from southern coast of China. Chinese Journal of Oceanology and Limnology, 2012, 30(2): 206-211.
9. Tao Yuan, Maoxian He*, Liangmin Huang*. Identification of an Aflp Fragment Linked to Shell Color in the Noble Scallop Chlamys nobilis Reeve. J. Shellfish Res. 2012, 31(1): 33-37.
10. Wenguang Liu, Xiande Huang, Jianshi Lin, Maoxian He*. Ocean acidification and elevated temperature affected gene expression patterns of the pearl oyster Pinctada fucata. PLos One, 2012, 7(3): e33679.
11. Xian-De Huang, Wen-Guang Liu, Yun-Yan Guan, Yu Shi, Qi Wang, Mi Zhao, Shan-Zeng Wu, Mao-Xian He*. Molecular cloning and characterization of class I NF-κB transcription factor from pearl oyster (Pinctada fucata). Fish and Shellfish Immunology, 2012, 33: 659-666.
12. Xian-De Huang,Wen-Guang Liu, Yun-Yan Guan, Yu Shi, QiWang, Mi Zhao, Shan-Zeng Wu, Mao-Xian He*. Molecular cloning, characterization and expression analysis of Tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster. Fish and Shellfish Immunology, 2012, 33: 652-658.
13. Xian-De Huang & Mi Zhao & Wen-Guang Liu &Yun-Yan Guan & Yu Shi & Qi Wang & Shan-Zeng Wu & Mao-Xian He. Gigabase-Scale Transcriptome Analysis on Four Species of Pearl Oysters. Mar Biotechnol, 2013, 15: 253-264.
14. Wen-Guang Liu, Xian-De Huang, Qi Wang, Mi Zhao, Shan-Zeng Wu, Yun-Yan Guan, Yu Shi, Mao-Xian He*. Gene cloning and function analysis of Cytokine-induced suppressor of cytokine signaling (SOCS) from pearl oyster Pinctada fucata. Fish and Shellfish Immunology, 2013, 34: 849-854.
15. Shan-Zeng Wu？, Xian-De Huang？, Qin Li, Mao-Xian He*. Interleukin-17 in pearl oyster (Pinctada fucata): Molecular cloning and functional characterization. Fish and Shellfish Immunology, 2013, 34:1050-1056.
16. Xian-De Huang, Wen-Guang Liu, Qi Wang, Mi Zhao, Shan-Zeng Wu, Yun-Yan Guan, Yu Shi, Mao-Xian He*. Molecular characterization of interferon regulatory factor 2 (IRF-2) homolog in pearl oyster Pinctada fucata. Fish and Shellfish Immunology, 2013, 34:1279-1286.
17. Shanzeng Wu, Yunyan Guan, Xiande Huang, Maoxian He*. Development of 25 novel microsatellite loci and genetic variation analysis in breeding populations of the pearl oyster Pinctada fucata. Journal of the World Aquaculture Society, 2013, 44(4): 600-609.
18. Yu Shi, Yunyan Guan, Maoxian He*. Molecular identification of insulin-related peptide receptor and its potential role in regulating development in Pinctada fucata. Aquaculture, 2013, 408-409: 118-217.
19. Yu Shi, Maoxian He*. Differential gene expression identified by RNA-Seq and qPCR in two sizes of pearl oyster (Pinctada fucata). Gene, 2014, 538: 313-322.
20. Yu Shi, Qi Wang, Maoxian He*. Molecular identification of dmrt2 and dmrt5 and effect of sex steroids on their expressions in Chlamys nobilis. Aquaculture, 2014, 426-427: 21-30.
21. Qi Wang, Maoxian He*. Molecular characterization and analysis of a putative 5-HT receptor involved in reproduction process of the pearl oyster Pinctada fucata. General and Comparative Endocrinology, 2014, 204:71-79.
22. Qin Li, Yaoguo Li, Xiande Huang and Maoxian He*. Molecular Cloning and Single Nucleotide Polymorphisms (SNPs) Identification of Myostatin cDNA in the Pearl Oyster, Pinctada fucata. Journal of the World Aquaculture Society, 2014, 45(6): 638-651.
23. Mi Zhao, Maoxian He*, Xiande Huang, Qi Wang. A Homeodomain Transcription Factor Gene, PfMSX, Activates Expression of Pif Gene in Pearl Oyster Pinctada fucata. PLoS One, 2014, 9(8): e103830.
24. Yaoguo Li，Maoxian He*. Genetic mapping and QTL analysis of growth-related traits in Pinctada fucata using restriction-site associated DNA sequencing. PLoS One, 2014, 9(11): e111707.
25. Xian-de Huang, Guo-jian Wei, Hua Zhang, Mao-xian He*. Nuclear factor of activated T cells (NFAT) in pearl oyster Pinctada fucata: Molecular cloning and functional characterization. Fish and Shellfish Immunology, 2015, 42: 108-113.
26. Yaoguo Li, Xiande Huang, Yunyan Guan, Yu Shi, Hua Zhang, Maoxian He*. DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata. Fish and Shellfish Immunology, 2015, 45: 912-918.
27. Xian-De Huang, Hua Zhang, Mao-xian He*. Comparative and Evolutionary Analysis of the IL17 Gene Family in Invertebrate. PLoS One. 2015, 10(7): e0132802.
28. Xian-De Huang, Guo-Jian Wei, Mao-Xian He*. Cloning and gene expression of signal transducers and activators of transcription(STAT) homologue provide new insights into the immune response and nucleus graft of the pearl oyster Pinctada fucata. Fish and Shellfish Immunology, 2015, 47: 847-854.
29. Mi Zhao, Maoxian He*, Xiande Huang, Qi Wang, Yu Shi. Functional Characterization and Molecular Mechanism Exploration of Three Granulin Epithelin Precursor Splice Variants in Biomineralization of the Pearl Oyster Pinctada fucata. Molecular Genetics and Genomics.2016, 291(1): 399-409.
30. Yu Shi, Maoxian He*. PfIRR Can Interact with HrIGF-I and Activate Both MAP kinase and PI3-kinase Signaling Pathways in Pinctada fucata. Scientific Reports, 2016, 6: 22063.
31. Mi Zhao, Yu shi, Maoxian He*, Xiande Huang, Qi Wang. PfSMAD4 plays a role in biomineralization and can transduce bone morphogenetic protein-2 signals in the pearl oyster Pinctada fucata. BMC developmental biology, 2016, 16: 9.
32. Hua Zhang, Mi Zhao, Xuejie Yi, Zekui Ou, Yaoguo Li, Yu Shi*, Maoxian He*. Characterization of the distal-less homologue gene, PfDlx, involved in regulating the expression of Pif in the pearl oyster, Pinctada fucata. Comparative Biochemistry and Physiology, Part B, 2017, 212: 51-58.
33. Wenguang Liu, Zonghe Yu, Xiande Huang, Yu Shi, Jianshi Lin, Hua Zhang, Xuejie Yi, Maoxian He *. Effect of ocean acidification on growth, calcification, and gene expression in the pearl oyster, Pinctada fucata. Marine Environmental Research, 2017, 130: 174-180.
34. Hua Zhang, Yu Shi, Maoxian He. Insulin growth factor binding protein (IGFBP) is involve in endocrine function regulated by insulin-like peptide system of pearl oyster Pinctada fucata. Comparative Biochemistry and Physiology, Part B. 2017, 214: 27-35.
35. Hua Zhang, Xiande Huang, Yu Shi, Wenguang Liu, Maoxian He*. Identification and analysis of an MKK4 homologue in response to the nucleus grafting operation and antigens in the pearl oyster, Pinctada fucata. Fish and Shellfish Immunology, 2018, 73: 279-284.
36. Shi Yu, Liu Wenguang, He Maoxian*. Proteome and Transcriptome Analysis of Ovary, Intersex Gonads, and Testis Reveals Potential Key Sex ReversalDifferentiation Genes and Mechanism in Scallop Chlamys nobilis. Marine Biotechnology, 2018, 20(2): 220-245.
37. Hua Zhang, Zekui Ou, Meng Xu, Xiande Huang, Wenguang Liu, Yu Shi, Maoxian He？. Molecular cloning and characterization of a putative mitogen-activated protein kinase (Erk12) gene: Involvement in mantle immunity of Pinctada fucata. Fish and Shellfish Immunology, 2018, 80: 63-70. |
| 承担科研项目情况： |
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1）中科院A类先导专项子课题：南海生态环境变化-关键生态种群繁育-螺类繁育（2016-2020，XDA13020206）
2）国家贝类产业技术体系岗位科学家：海水珍珠贝种质资源与品种改良（2017-2020，CARS-49） |
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